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Protein kinases / Apoptosis / Proteins / Transcription factors / Autophagy / Mitogen-activated protein kinase kinase / P53 / P38 mitogen-activated protein kinases / P21 / Biology / Cell biology / Programmed cell death


Targeting MKK3 as a novel anticancer strategy: molecular mechanisms and therapeutical implications
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Document Date: 2015-01-29 08:34:19

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File Size: 2,05 MB

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City

Monza / Dallas / Glattbrugg / Rome / Lecco / Walkersville / Milan / Eggenstein / San Diego / Les Ulis / Long Beach / St. Louis / Santa Cruz / /

Company

Hoosier Oncology Group / Life Technologies Inc. / Sigma-Aldrich / Experimental Oncology Laboratories / Pearson / Pharmacia / Bio-Rad / Amersham Biosciences / Lonza Corporation / Macmillan Publishers Limited / /

Country

Germany / Switzerland / Italy / France / United States / /

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Facility

Cancer Institute / Regina Elena National Cancer Institute / Regina Elena Cancer Institute / /

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IndustryTerm

ubiquitin-like systems / treatment of metastatic colorectal cancer / cancer treatment / Chemical autophagy inhibition / activation site / dual specificity protein kinase / light chain / tissue culture media / /

MedicalCondition

Successful cancer / mutp53-carrying tumors / H1299 p53-null cancer cells / After tumor / tumor volumes / colorectal cancer / established tumors / control tumors / RKO colon cancer / mutp53 cancer / MAP-ing glioma invasion / colon cancer / gliomas / xenograft tumor / non-small-cell lung carcinoma / xenograft tumors / sh/MKK3 tumors / MKK3 deficiency / vivo experimental tumor / wtp53 tumor / adenocarcinoma / tumor / MKK3-depleted tumors / HT29 cancer / cancer / colon adenocarcinoma / colorectal carcinoma / tumors / Disease / human cancer / metastatic colorectal cancer / vivo HT29 cancer / wtp53-bearing cancer / Lentiviral infection / tumor necrosis / breast and colon cancer / p38 drive glioma invasion / per se significantly reduced tumor / colorectal tumors / wtp53 cancer / /

MedicalTreatment

radiation therapy / anticancer therapy / chemotherapy / radiotherapy / chemotherapies / radiation / anticancer therapies / adjuvant therapy / /

NaturalFeature

Charles River / /

Organization

National Institute of Health / Regina Elena Cancer Institute / US Federal Reserve / Ethical Committee / Regina Elena National Cancer Institute / Cancer Institute / Nomenclature Committee on Cell Death / /

Person

Fanciulli / Bruno / Invitrogen / Simone C. Signal-dependent / Regina Elena / /

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Position

*Corresponding author / Abraham RT / general molecular player / representative / M-MLV-RT / /

Product

cisplatin / Penicillin / doxycycline / fluorouracil / hydrocortisone / /

ProvinceOrState

South Dakota / /

RadioStation

Cuervo AM / /

Technology

radiation / siRNA / antibodies / Biotechnology / Cell Signaling / human genome / apoptosis / ATG / gene expression / chemotherapy / condensation / gel electrophoresis / evaluated using phospho-specific antibodies / /

URL

www.nature.com/cddis / /

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