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DNA repair / Programmed cell death / Cell cycle / PARP inhibitor / P53 / RAD51 / Ataxia telangiectasia mutated / Homologous recombination / BRCA1 / Biology / Tumor suppressor genes / Proteins


This is the author’s version of a work that was submitted/accepted for publication in the following source: Jekimovs, Christian, Bolderson, Emma, Suraweera, Amila, Adams, Mark, O’Byrne, Kenneth J., & Richard, Derek J
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Document Date: 2014-10-07 04:35:37


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Company

Eli Lilly / SSB / DNA / NHEJ / Creative Commons / AstraZeneca / Elite Pharmaceuticals Inc. / /

Country

Japan / /

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Event

FDA Phase / Product Issues / /

Facility

Mirin MRN complex / University College London / The University of Texas MD Anderson Cancer Center / Institute of Health / National Cancer Institute library / MRN complex / G2/M checkpoint / Children’s Medical Research Institute / Queensland University of Technology / /

IndustryTerm

treatment of cancers / human cancer prevention / cancer therapy / cancer therapies / treatment of human mutant p53 lung cancer / cancer treatment / repair machinery / break site / lesion site / tissue culture media / /

MedicalCondition

microcephaly / ovarian cancers / ovarian cancer / BRCA1- and BRCA2-deficient cancer / human pancreas tumor / neurological disorders / cisplatin-resistant human squamous cell cancer / dramatic tumor / melanoma / xenograft tumors / human mutant p53 lung cancer / esophageal cancer / reduced tumor / head cancers / breast cancer / glioblastoma / leukemia / tumor / conventional cancer / significant tumor / Cancer / tumors / p53-defective tumors / advanced solid tumors / human cancer / resistant tumors / assumed HR-deficient tumors / human squamous cell carcinoma / vivo studies involving breast cancer / advanced BRCA1-mutant cancers / stable disease / neck cancers / refractory solid tumors / p53 mutant tumors / mutant breast cancers / BRCA1-deficient cancer / effectively sensitized tumor / Ataxia telangiectasia / p53-mutated cancers / significantly delayed tumor / significantly inhibited tumor / IR-treated p53-deficient tumor / lymphoma / metastatic solid tumors / solid tumors / IV non-squamous non-small cell lung cancer / another syndrome / progressive cerebellar ataxia / triple-negative breast cancer / NBS-like NBS disorder / human breast cancer / relapsed acute myeloid leukemia / pancreatic cancer / Nijmegen breakage syndrome / cancers / squamous cell carcinoma / paired tumor / disease / acute leukemia / chemotherapy-resistant tumor / sporadic cancers / p53 The tumor / metastatic tumors / telangiectasia’s / lung cancer / colon cancer tumor / AT-like disorder / liver cancer / chemotherapyresistant tumor / cancer-prone syndrome / human glioma cells / syndrome / HR-defective cancers / /

MedicalTreatment

radiotherapy / radiation / cancer therapy / cancer therapies / radiation therapy / chemotherapy / gene therapy / /

Organization

Administration of CEP-8983 / University of Texas / National Cancer Institute / National Institute of Health / University College London / Queensland University of Technology / Brisbane / Institute of Health and Biomedical Innovation / Children’s Medical Research Institute / /

Person

Byrne Richard / Christian Jekimovs / Emma Bolderson / Mark Adams / Gyorgy Szabadkai / Derek J. Richard / /

Position

author / human head / Governor / /

Product

carboplatin / cisplatin / hydroxyurea / cytarabine / etoposide / Pyle P32 Television / AG014699 / BSI-201 / XL-844 / MK-4827 / NCT00937664 / LY2603618 / tumors / cancers / NCT01115790 / BRCA1 / DNA synthesis / SCH900776 / tumor cells / AZD7762 / xl - 844 / cells / CEP-9722 / /

ProvinceOrState

Texas / /

Technology

radiation / siRNA / high-throughput screening / apoptosis / drug discovery / gene expression / chemotherapy / treating cancer / recombination / ATM / DNA binding / gene therapy / pharmacokinetics / artificial intelligence / DNA synthesis / ionizing radiation / /

URL

www.frontiersin.org / http /

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