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Hsp90
Results: 152

#	Item
71	Abst[removed]First in human phase I study - results of a second-generation non-ansamycin Heat Shock Protein 90 (HSP90) inhibitor AT13387 in refractory solid tumors Daruka Mahadevan1, Diane M. Rensvold1, Sandra E. Kurtin1, Add to Reading List Source URL: astx.com Language: English - Date: 2012-12-13 18:06:00 Ancient Rome V Cohort Military of ancient Rome
72	The HSP90 Inhibitor, AT13387, Displays Single Agent Activity in Erlotinib-Sensitive and -Resistant Models of EGFR-Activated NSCLC Keisha Hearn, Tomoko Smyth, Jon Lewis, Vanessa Martins, Neil Thompson, Mohammad Azab, John Add to Reading List Source URL: astx.com Language: English Amines Organofluorides Alkynes Organochlorides Gefitinib Erlotinib Epidermal growth factor receptor Hsp90 Protein kinase inhibitor Chemistry Organic chemistry Quinazolines
73	Fragment-Based Drug Design of AT13387 - A Novel and Efficacious Inhibitor of Hsp90. A.J. Woodhead , H. Angove, O. Callaghan, M. Carr, G. Chessari, M. Congreve, J. Cosme, S. Cowan, J. Coyle, P. Day, R. Downham, T. Early, Add to Reading List Source URL: astx.com Language: English - Date: 2012-12-13 18:06:00 Medicinal chemistry Heat shock proteins Clinical research Hsp90 Hsp70 Drug design Fragment-based lead discovery Virtual screening IC50 Pharmaceutical sciences Pharmacology Drug discovery
74	Combining the HSP90 inhibitor, AT13387, with vemurafenib delays the emergence of V600E resistance in a preclinical model of BRAF mutant melanoma. Tomoko Smyth, Jon Lewis, Keisha Hearn, Neil Thompson, John Lyons, Mohammad Add to Reading List Source URL: astx.com Language: English - Date: 2013-09-21 15:10:26 Chemistry Tyrosine kinase inhibitors Organochlorides Organofluorides Sulfonamides Vemurafenib BRAF Hsp90 Melanoma Medicine Biology Oncogenes
75	THE HSP90 INHIBITOR, AT13387, IS EFFECTIVE IN MUTANT EGFR AND ALK-POSITIVE NSCLC MODELS. Tomoko Smyth, Ana Rodriguez-Lopez, Rachel McMenamin, Victoria Lock, Jayne Curry, Brent Graham, John Lyons, Neil Thompson and Nicola Add to Reading List Source URL: astx.com Language: English Organochlorides Amines Quinazolines Pfizer Gefitinib Crizotinib Protein kinase inhibitor ALK inhibitor Hsp90 Chemistry Organic chemistry Organofluorides
76	AT13387, an HSP90 inhibitor, is effective in both vemurafenib-sensitive and -resistant melanoma models Ana M. Rodriguez-Lopez, Tomoko Smyth, Jayne Curry, Brent Graham, Rachel McMenamin, John Lyons, Neil Thompson & Nicola Add to Reading List Source URL: astx.com Language: English - Date: 2012-12-13 18:06:00 Oncogenes Organochlorides Organofluorides Sulfonamides Vemurafenib BRAF Hsp90 inhibitors AKT Hsp90 Medicine Chemistry Biology
77	#3087 Phase I Study Assessing a Two-Consecutive Day (QD x 2) Dosing Schedule of the Hsp90 Inhibitor, AT13387, in Patients with Advanced Solid Tumors K Do1, G Speranza1, A Chen1, J Trepel1, M-J Lee1, S Lee1, L Phillips1, Add to Reading List Source URL: astx.com Language: English - Date: 2012-12-13 18:06:00 Heat shock protein Trastuzumab Hsp70
78	Fragment-based Drug Discovery of the Synthetic Small Molecule HSP90 Inhibitor AT13387 A211 Christopher W. Murray, Maria G. Carr, Gianni Chessari, Miles Congreve, Joseph E. Coyle, Philip J. Day, Lynsey Fazal, Martyn Frede Add to Reading List Source URL: astx.com Language: English Proteins Heat shock proteins Drug discovery Clinical research Hsp90 inhibitors Hsp70 Hsp90 Fragment-based lead discovery Chaperone Pharmaceutical sciences Pharmacology Medicine
79	The HSP90 inhibitor, AT13387, combined with erlotinib improves response in EGFR-driven xenograft models of NSCLC[removed]Tomoko Smyth, Jon Lewis, Keisha Hearn, Aurélie Courtin, Neil Thompson, John Lyons, Nicola Wallis 1As Add to Reading List Source URL: astx.com Language: English - Date: 2014-06-09 09:13:18 Amines Lung cancer Alkynes Erlotinib Ethers Epidermal growth factor receptor Non-small-cell lung carcinoma Hsp90 Chemistry Organic chemistry Quinazolines
80	Microsoft PowerPoint - NWallis TAT O11-5 Final Add to Reading List Source URL: astx.com Language: English - Date: 2014-06-09 11:38:56 Organofluorides Piperidines Lung cancer Crizotinib Pyrazoles Protein kinase inhibitor Anaplastic lymphoma kinase Erlotinib Hsp90 Chemistry Organic chemistry Pfizer

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