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Integral membrane proteins / Peptide hormones / Molecular biology / Insulin / Glucokinase / Diabetes mellitus type 1 / Diabetes mellitus / Sec61 / Downregulation and upregulation / Biology / Diabetes / Biochemistry


ORIGINAL ARTICLE A Point Mutation in Sec61␣1 Leads to Diabetes and Hepatosteatosis in Mice David J. Lloyd,1,2 Matthew C. Wheeler,3 and Nicholas Gekakis3
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Broad Institute of Harvard / Lund University / Osaka University / Genomics Institute / Scripps Research Institute / /

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aberrant insulin processing / protein processing / anti-immunoglobulin heavy chain / online appendix / insulin processing / endogenous gene product / protein translocation machinery / high-glucose media / /

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severe hyperglycemia / glucose intolerance / lissencephaly / optic atrophy / DF / neonatal diabetes / severe insulin resistance / progressive hepatic dysfunction / cell apoptosis diabetes / early-onset diabetes / induced diabetes / diet-induced insulin resistance / cirrhosis / Wolfram syndrome / maturity-onset diabetes / pancreatic beta-cell tumours / obesity / http /

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Purcell S. Genome-wide association / MIT / Harvard / Broad Institute / U.S. Securities and Exchange Commission / American Diabetes Association / Osaka University / Novartis Research Foundation / Use Committee / US Federal Reserve / Scripps Research Institute / Genomics Institute of the Novartis Research Foundation Institutional Animal Care / 3The Scripps Research Institute / 1Genomics Institute / Lund University / Genomics Institute of the Novartis Research Foundation Specific Pathogen-Free / /

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Ron D. Diabetes / Malcolm Wood / Brian Steffy / Jeff Pitman / ABI PRISM / Sandy Bohan / Ron D. Endoplasmic / Mingyue Zhou / Lacey Kischassey / Ron D. Protein / Tim Wiltshire / Bill Kiosses / Nicholas Gekakis / /

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Cooke MP / rt / D.J. / Corresponding author / King / Hunter / Cao / reporter / Marshall / /

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M-60 / glucagon / response / /

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South Dakota / California / /

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alpha / Autoimmunity and inflammation / Genomics / Antibodies / Biotechnology / genotyping / apoptosis / Single nucleotide polymorphism / Gene Expression / package protocol / http / genotype / /

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