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Endocrine system / G protein coupled receptors / PEGylation / Pharmacokinetics / Vasoactive intestinal peptide / Bronchoalveolar lavage / Pituitary adenylate cyclase-activating peptide / Roxithromycin / Secretin family / Biology / Peptide hormones / Chemistry


Chemical synthesis and formulation design of a PEGylated vasoactive intestinal peptide derivative with improved metabolic stability
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Document Date: 2013-06-04 16:55:48

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Erythritol / Derendorf / Osaka / Tokyo / Dolovich / Manchester / Kyoto / Dudingen / Kim / Kanagawa / Shizuoka / Waltham / St. Louis / Saitama / Rosebrough / Rockville / Männedorf / New York / Louis / Sunnyvale / Milford / Nagoya / /

Company

ILS Inc. / Keyence Corporation / Wako Pure Chemical Industries / Sigma Aldrich / Brandel Co. / Mantey S.A. / J. Pharm / INA Research Inc. / Bayer / Shiseido / Hitachi / Japan American Peptide Company / Behring Ag / Ó 2013 Elsevier B.V. / /

Country

Switzerland / Netherlands / Japan / United Kingdom / Guinea / United States / /

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Facility

terminus of VIP / Naunyn Schmiedebergs Arch / Laboratory of Physiology / terminus of IK312532 / University of Shizuoka / /

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IndustryTerm

lactose carrier particles / airway systems / drug delivery devices / polyethyleneimine solution / k2d software / treatment of inflammatory disease / chemical modification studies / chemical modification / formalin neutral buffer solution / food / inhalation device / Dry powder inhalation systems / potential clinical applications / drug delivery systems / unsupervised learning neural network / chemical approaches / treatment of airway inflammatory diseases / Chemical synthesis / peripheral nervous systems / respiratory systems / large lactose carrier particle / suitable inhalation device / insufflation powder delivery device / peptide solution / appropriate site / chemical modifications / /

MedicalCondition

cytotoxic injury / pulmonary delivery / pulmonary tissues / airway inflammatory diseases / injury / eosinophilia / morphological changes / asthma / antigen-induced pulmonary neutrophilia / pulmonary administration / observed pulmonary neutrophilia / pulmonary tissue / COPD / proper chronic asthma/COPD model animals / Pulmonary drug delivery / bronchial asthma / disease / chronic obstructive pulmonary disease / pulmonary injury / chronic asthma/COPD model animals / experimental asthma/COPD model rats / asthma/ COPD / /

MedicalTreatment

drug delivery systems / inhalation therapy / drug therapy / /

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Cascade / /

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Mount Quick™ / /

Organization

Department of Pharmacokinetics / Institute for Environmental Sciences / Ministry of Education / Laboratory of Physiology / University of Shizuoka / School of Pharmaceutical / Department of Pharmacokinetics and Pharmacodynamics / Graduate School / Institutional Animal Care and Ethical Committee / /

Person

Takahiro Mizumoto / Satomi Onoue / Kojo / Takuya Matsui / Masashi Kato / Sakura Finetek / Hashimoto / Ion Sputter / Liang Liu / /

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Position

mediator / pro-inflammatory and pro-oxidant mediator / Representative / Corresponding author / Fisher / /

Product

glucagon / Neulasta / J-720 / HPMC capsules / sodium pentobarbital / Nikon D50 Digital Camera / balanced salt / dimethyl sulfoxide / Nikon D90 Digital Camera / /

ProvinceOrState

M.B. / New York / South Carolina / California / New Jersey / North Carolina / Massachusetts / /

Technology

drug delivery / neural network / Alpha / molecular modeling / antibodies / Pharmacokinetics / laser / Pharmacodynamics / /

URL

http /

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