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Immunosuppressants / Chemistry / Gerontology / Mammalian target of rapamycin / Signal transduction / Kidney cancer / Sirolimus / Insulin-like growth factor 1 / Zotarolimus / Medicine / Biology / Macrolides


Review series Rapalogs and mTOR inhibitors as anti-aging therapeutics Dudley W. Lamming,1,2 Lan Ye,3 David M. Sabatini,1,2 and Joseph A. Baur3 1Whitehead Institute for Biomedical Research, Department of Biology, Howard
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Document Date: 2015-04-21 13:21:14

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Gesualdo L. Management / Grandaliano G / BP / Pearson / /

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FDA Phase / /

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Howard Hughes Medical Institute / National Institute / Hall MN / Institute of MIT / The David H. Koch Institute / FKBP12 complex / Massachusetts Institute of Technology / University of Pennsylvania / TSC complex / /

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consensus algorithm / chemical modulators / cancer therapy / Active-site / food / treatment of cancer / Diabetes Care / treatment of age-related diseases / cancer prevention / natural product / pharmaceutical agent / cancer treatment / treatment of age-related disease / mechanism accounting / /

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JE / viral infection / diet-induced hyperglycemia / angiotensin II-induced cardiac hypertrophy / lymphangioleiomyomatosis / melanoma / starvation / Peutz-Jeghers syndrome / HutchinsonGilford progeria / tuberous sclerosis / diarrhea / breast cancer / tumor / autoimmune disorders / rare premature aging syndrome / cardiac hypertrophy / cancer / chronic treatment / hyperglycemia / transplanted tumors / Chronic / human cancer / Diabetes / nail disorders / inflammatory component / myocardial contractile dysfunction / fungal infection / rash / joint pain / glucose intolerance / infantile hemangioma / DF / hyperinsulinemia / colorectal cancer / load-induced cardiac hypertrophy / strain / GCN4 ORF / chronic exposure / patients experiencing alopecia / chronic rapamycin treatment / Hutchinson-Gilford progeria / Obesity / et al. Activated FOXO-mediated insulin resistance / renal cell carcinoma / aphthous ulcers / influenza virus / age-related diseases / MS / every chronic disease / Hutchinson-Gilford progeria syndrome / pancreatic cancer / cancers / Alzheimer’s disease / insulin resistance / disease / single disease / endometrial hyperplasia / hyperlipidemia / Mucositis / spontaneous mammary tumors / tumor necrosis / myocardial infarction / diabetes mellitus / progeria and normal cells / neurodegenerative diseases / inflammation / Chronic / low-grade inflammation / age-related disease / anemia / /

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low-calorie diet / cancer therapy / low protein diet / immunosuppression / transplant surgery / renal transplant / caloric restriction / immunization / renal transplantation / rejuvenation / /

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Research Center / David H. Koch Institute for Integrative Cancer Research / Massachusetts Institute of Technology / American Federation for Aging Research / Department of Physiology / US Federal Reserve / Baur / Ellison Medical Foundation / FDA / University of Pennsylvania / Philadelphia / Koch Institute Frontier Research Program / Institute for Diabetes / Obesity / and Metabolism / National Institute of Health / National Institute on Aging Intervention Testing Program / W. Lamming / 1 / 2 Lan Ye / 3 David M. Sabatini / 1 / 2 and Joseph A. Baur3 1Whitehead Institute for Biomedical Research / Harvard / Perelman School of Medicine / Department of Biology / 2Broad Institute / American Diabetes Association / National Institute on Aging and a New Scholar / European Association for the Study of Diabetes / Starr Foundation / Baur and Sabatini / Howard Hughes Medical Institute / /

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Dudley W. Lamming / Syed Alwi / Thomas G. Rapamycin / Izumo S. Rapamycin / D.M. Sabatini / Kimball SR / Kenyon C. Lifespan / Ben Sahra / Ann Pharmacother / /

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Rothwell PM / et al / King / Jefferies HB / investigator / Harper / Wymann MP / Cao / /

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simvastatin / FS / Hutchinson-Gilford / mTORC1 / /

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The Journal of Clinical Investigation / PLoS One / /

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