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81	Decision tree to determine whether an investigational drug is an inhibitor of OCT2, OAT1, or OAT3 and when an in vivo clinical study is needed — (Modified From Figures in Giacomini KM, et al, Nat. Rev Drug Discov. 9: 2 Add to Reading List Source URL: www.fda.gov Language: English Organic anion transporter 1 Solute carrier family Chemistry Didanosine IC50 Investigational New Drug Metformin Pharmacology Medicine Bristol-Myers Squibb
82	Figure 7: Decision tree to determine whether an investigational drug is an inhibitor of P-gp and when an in vivo clinical study is needed. A similar model can be applied to a BCRP inhibitor) — (Modified From Figures in Add to Reading List Source URL: www.fda.gov Language: English IC50 Pharmacodynamics
83	Figure 9: Decision tree to determine whether an investigational drug is an inhibitor of OATP1B1 or OATP1B3 and when an in vivo clinical study is needed —(Modified From Figures in Giacomini KM, et al, Nat. Rev Drug Disc Add to Reading List Source URL: www.fda.gov Language: English Statins Organic chemistry Rosuvastatin IC50 Pitavastatin Pravastatin Chemistry Carboxylic acids Diols
84	U.S. Food and Drug Administration Notice: Archived Document The content in this document is provided on the FDA’s website for reference purposes only. It was current when produced, but is no longer maintained and may Add to Reading List Source URL: www.fda.gov Language: English Pharmacology Enzymes IC50 Pharmacodynamics Cytochrome P450 Chemistry Metabolism Biology
85	Lei Zang: Transporter DDI Evaluation in New Drug Application Submissions Add to Reading List Source URL: www.fda.gov Language: English Digoxin P-glycoprotein Pharmaceutical sciences Pharmacology IC50 Pharmacodynamics
86	Microsoft PowerPoint - Huang_Nov_16_2007_final_final.ppt Add to Reading List Source URL: www.fda.gov Language: English Pharmacology Amides Dipeptidyl peptidase-4 inhibitors Anti-diabetic drugs Torsades de pointes Sitagliptin Lapatinib CYP3A4 IC50 Chemistry Organic chemistry Organofluorides
87	Microsoft PowerPoint - Huang_November_10_2007_AAPS_drug interactions_ Nov_8_2007_v1.ppt Add to Reading List Source URL: www.fda.gov Language: English Cytochrome P450 Amides Carbamates Organofluorides Darunavir Ranolazine IC50 Sitagliptin Ritonavir Chemistry Organic chemistry Protease inhibitors
88	The Role of Drug Transporters in Drug Safety-Perspective from the FDA Add to Reading List Source URL: www.fda.gov Language: English Digoxin ABC transporters Torsades de pointes Antiarrhythmic agent Amiodarone IC50 Dabigatran P-glycoprotein Chemistry Organic chemistry Cardenolides
89	Advisory Committee Mtgs. Sample PPT Add to Reading List Source URL: www.fda.gov Language: English IC50 Pharmacodynamics Biology Digoxin In vivo Enzyme In vitro Chemistry Pharmacology Metabolism
90	Figure 4. Using a PBPK Model to Explore Drug-Drug Interaction Potential Between a Substrate Drug and an Interacting Drug Add to Reading List Source URL: www.fda.gov Language: English Medicinal chemistry Chemistry Pharmacy Toxicology IC50 Physiologically based pharmacokinetic modelling ADME Partition coefficient Bioavailability Pharmaceutical sciences Pharmacology Pharmacokinetics

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