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City Ann Arbor / Coquette / Paris / Cary / Les Ulis / Sacramento / Baltimore / San Diego / / Company SAS Institute Inc / Roche Diagnostics / AmericanEuropean Consensus Group / Biomedical Diagnostics / Sanofi / Abbott Laboratories / Inova Diagnostics / IgG / Gharavi AE / Diebold / International Scoring Systems / / Country France / / / Facility American College of Rheumatology / / IndustryTerm tomographic imaging / / MedicalCondition Severe leukocytoclastic vasculitis / antiphospholipid syndrome / MC vasculitis / multiple myeloma / vasculitides / symptomatic mixed cryoglobulinemias / arthritis / pneumococcal pneumonia / rheumatoid arthritis / pneumocystosis / connective tissue diseases / B cell non-Hodgkin’s lymphomas / Severe sepsis / low-grade marginal zone lymphoma / Hepatitis B / AL amyloidosis / polyneuropathy / MC syndrome / low-grade lymphoma / aspergillosis / DEFINITIONS OF ETIOLOGIC FACTORS Connective tissue diseases / mg/L Anemia / B-cell lymphomas / mixed cryoglobulinemia / chronic HCV infection / systemic sclerosis / non-B viral hepatitis / Behc¸et disease / Female sex Clinical manifestation Arthralgia / Castleman disease / mononeuritis / vasculitis / amebiasis / arthralgia / bacterial septicemia / cold agglutinin disease / definite antiphospholipid syndrome / neoplastic diseases / primary and secondary disease / lymphomas / HCV / chronic infections / HCV infection / Patients With Mixed Cryoglobulinemia / essential mixed cryoglobulinemia / g/L Hypogammaglobulinemia / purpura / renal involvement / lymphoproliferative disorders / non-Hodgkin lymphoma / mixed connective tissue disease / lymphoma included physical examination / MC Without Vasculitis / Sjo¨gren syndrome / infection / Behc¸et’s Disease / chronic infection / hepatitis C virus. lymphoproliferative / Complete lymphoma remission / marginal zone lymphomas / Cryoglobulinemia / HCV RNA / systemic lupus erythematosus / chronic antigenic stimulation / Lymphoma / lymphoma development / negative nodal marginal zone B-cell lymphoma / palpable purpura / Raynaud phenomenon / Immunological disorders / angioimmunoblastic lymphadenopathy / lymphoproliferative disease / mixed cryoglobulinemias / hepatitis C / sarcoidosis / peripheral neuropathy / hematologic dis / lymphoplasmocytic lymphoma / Sjogren’s Syndrome / fatigue / hematologic diseases / hematologic disorders / Additional neoplasms / marginal zone lymphoma / sicca syndrome / infections / chronic lymphoid leukemia / cells/mL Thrombocytopenia / sepsis / autoimmune diseases / purpura / Variables Associated With B-Cell Non-Hodgkin Lymphoma / proteinuria / Patients With B-Cell Non-Hodgkin Lymphoma / primarily lymphoplasmocytic lymphoma / involvement Nodal involvement Extranodal involvement Ann Arbor disease / lymphoma histologic subtypes / disease / cryoglobulinemia HCV infection / scleroderma / essential mixed cryoglobulinemic glomerulonephritis / hematuria / Malignant lymphoma / g/dL Leukopenia / MALT lymphomas / cardiovascular disease / extranodal lymphoproliferative disease / Still disease / renal insufficiency / lymphoid tissue lymphomas / primary Sjogren’s syndrome / Infectious diseases / hypogammaglobulinemia / systemic vasculitis / MC With HCV Infection / I cryoglobulinemia / MC Without HCV Infection / B-cell lymphoma / Splenic lymphoma / syndrome / tuberculosis / skin vasculitis / / MedicalTreatment rewarming / chemotherapy / plasmapheresis / / Organization World Health Organization / Department of Internal Medicine / Clinical Advisory Committee / American Rheumatism Association / the American College / Centre National / American Rheumatism Association Diagnostic and Therapeutic Criteria Committee / Single University Hospital / American Medical Association / / Person Antoine Benard / Mixed Cryoglobulinemia David Saadoun / Jean-Charles Piette / Patrice Cacoub / Arch Intern Med / Mathieu Resche-Rigon / Pascale Ghillani-Dalbin / Richard Crecel / Cooper N. Cryoglobulinemia / ARCH INTERN / Arch Dermatol / Ann Rheum / Ann Intern / / Position Author / using Fisher / McCluskey RT / / Product vincristine sulfate / azathioprine sodium / prednisone / cyclophosphamide / / ProvinceOrState Virginia / / SportsEvent NHL / NHL 23 / / Technology chemotherapy / antibodies / / URL WWW.ARCHINTERNMED.COM / http / SocialTag 
ORIGINAL INVESTIGATION Increased Risks of Lymphoma and Death Among Patients With Non–Hepatitis C Virus–Related Mixed Cryoglobulinemia David Saadoun, MD; Je´re´mie Sellam, MD; Pascale Ghillani-Dalbin, MD; Richard C