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Signal transduction / Integral membrane proteins / Tyrosine kinase receptors / Transcription factors / MAPK/ERK pathway / IRS1 / Insulin receptor / Glucokinase / Insulin resistance / Biology / Cell biology / Protein kinases


ORIGINAL ARTICLE Direct Recruitment of Insulin Receptor and ERK Signaling Cascade to Insulin-Inducible Gene Loci Joel D. Nelson,1,2 Rene´e C. LeBoeuf,2,3 and Karol Bomsztyk1,2
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Goldfine / /

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Eli Lilly / Millipore / Kusari AB / The Jackson Laboratory / Proc Natl Acad Sci U S A / HTC / LifeScan Inc. / IR / Corning / Kao / /

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pence / SOS / /

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Event

Product Issues / /

Facility

Bar Harbor / University of Washington / /

IndustryTerm

software tools / immediate early gene product / online appendix / downstream site / mRNA synthesis/processing / /

MedicalCondition

Histone H3 diabetes / insulin-treated rat hepatic tumor / ob/ob diabetes / chronic hyperglycemic state / insulin resistance / Cancer / disease / either diabetes / diabetes.diabetesjournals.org DIABETES / novo DIABETES / Diabetes / diet-induced obesity / /

Organization

Internal Revenue Service / American Diabetes Association / Department of Medicine / 2UW Medicine Lake Union / US Federal Reserve / Animal Care and Use Committee / University of Washington / Seattle / /

Person

Joel D. Nelson / Johnny Bushey / Gene Loci Joel / Mark Caldwell / Steve Flanagin / Karol Bomsztyk / Phuong-Oanh T. Mai / /

Position

possible mediator / RT / Corresponding author / /

Product

Vizio L32 Television / H3 / Humulin N / Matrix ChIP / Pol / /

ProvinceOrState

Washington / /

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Bennett AM / /

Technology

end 48.18kb ChIP / alpha / 0.000 0.030 0.020 400 ChIP / 0.3 0.2 0.1 0.0 0 15 30 45 60 ChIP / 0.01 0.00 0.04 2 pIRβ ChIP / antibodies / 0.002 0.001 0.000 ChIP / 0.001 0.000 0.000 0.004 0.003 0.050 ChIP / 0 bp ChIP / gene expression / Matrix ChIP / Gck using Matrix ChIP / flash / /

URL

diabetes.diabetesjournals.org / http /

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