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City Blocking / Neutralizing / Tokyo108-8639 / Tokyo / Linking / Alternatively / L.A. / Technology / New Haven / Interestingly / / Company CHS / receptor Ab / IL-17B neutralizing Ab / IL-17F / Elsevier Inc. / Th17 / Wilson / Fina / Williams A.S. / Immunity Review / SLE / Linde / Y759F Immunity Review / humanized Ab / The Special Coordination Funds / Innovative Biosciences / IL-17A Ab / / Country Netherlands / Japan / United States / / / Event Product Issues / FDA Phase / / Facility C terminus / Chiba University / University of Tokyo / N terminus / TCR complex / Institute of Medical Science / / IndustryTerm treatment of inflammatory diseases / treatment of certain autoimmune diseases / treatment of RA and Crohn’s disease / experimental protocols / / MedicalCondition autoimmune diabetes / certain autoimmune diseases / acute colitis / MB49 bladder carcinoma / rheumatoid nodules / atopic dermatitis / psoriasiform dermatitis / arthritis / local inflammation / rheumatoid arthritis / several tumor / collagen-induced arthritis / airway inflammation / pulmonary fibrosis / inflammatory mediators / Mycobacterium tuberculosis infection / IL-17F-dependent diabetes / inflammatory bowel diseases / C. rodentium infection / chronic inflammatory arthropathy / Autoimmune Diseases Multiple sclerosis / inflammatory cytokine expression / Tumor Development Th17 / human diseases / Psoriasis / Inflammatory Diseases / chronic colitis / spontaneous IL-17A-dependent psoriasis / asthma / bacterial and fungal infections / leukemia / tumor / autoimmune disorders / allergic diseases / cancer / tumors / IL-17A-overexpressing tumor / hepatocellular carcinoma / Allergic Diseases Delayed-type hypersensitivity / hyperglycemia / Lung metastasis / diabetes / candida infections / allergic disorders / T cell-induced colitis / B16 melanoma / S. aureus / diseases / increased tumor / infection / deficiency / Escherichia coli infection / contact hypersensitivity / enhanced tumor / inflammatory responses / eosinophilia / disorders / chronic allergic response / uveitis / allergic disease / IBD / attenuated colonic inflammation / cell-driven inflammation / systemic lupus erythematosus / inflammatory leukocytes / Gram-negative bacterial pneumonia / hyper IgE syndrome / lymphoma / eosinophilic acute airway inflammation / certain diseases / Airway eosinophilia / metastasis / advanced ovarian cancer / skin and lung inflammation / inflammatory sites / familial adenomatous polyposis / B16-F10 melanoma / colonic inflammation / colitis / established B16-F10 melanomas / microbial infection / Chronic Inflammatory Diseases IL-17E / chronic airway inflammation / MS / atopic asthma / K. pneumoniae infection / infections / autoimmune encephalomyelitis / systemic infection / psoriatic arthritis / early infections / sepsis / IL-23R dramatically reduced tumor / autoimmune diseases / NOD/SCID / accelerated wasting disease / bacteremia / severe combined immunodeficiency / allergic asthma / opportunistic infections / Disease / atherosclerosis / Crohn’s disease / colonic cancer / steroid-effective mild asthma / steroid-resistant severe asthma / oxazolone-induced colitis / neutrophil-mediated ischemia-reperfusion injury / oral candidiasis / lung cancer / tumor necrosis factor / diabetes mellitus / autoimmune disease / inflammatory epidermal hyperproliferative skin disease / scid / inflammation / OVA-induced airway eosinophilia / substantial inflammation / / MedicalTreatment immunization / adoptive transfer / biological therapies / / Organization University of Tokyo / Japan Science and Technology Agency / Chiba University / Medical Mycology Research Center / Central Intelligence Agency / Ministry of Education / Institute of Medical Science / Saitama / Group of 20 countries / Yale University School of Medicine / EAE / Center for Experimental Medicine and Systems Biology / Tumor Development Administration of IL-17E / / Person Van Maele / Yoichiro Iwakura / Nat / Lee / V / Miossec / Pociask / Askew / Williamson / Cells Target / / Position IL-17F Producer / D.J. / Cao / / Product IL-23 / IL-23R / IL-17F / IL-22 / Adenosine / antimicrobial peptide production / mice / IL-12 / Th2 cell / Th9 cell activation / BMDC-conditioned medium / neutrophil recruitment / / ProgrammingLanguage DC / / ProvinceOrState Connecticut / Mississippi / / PublishedMedium the Y759F Immunity Review / / Technology Technology of Japan / experimental protocols / recombination / Transplantation / / SocialTag 
Immunity Review Functional Specialization of Interleukin-17 Family Members Yoichiro Iwakura,1,5,* Harumichi Ishigame,2 Shinobu Saijo,3 and Susumu Nakae4