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Apoptosis / Jurkat cells / Fas receptor / TRADD / Death effector domain / FADD / Tumor necrosis factor-alpha / NF-κB / Death-inducing signaling complex / Biology / Cell biology / Programmed cell death


The adaptor protein FADD and the initiator caspase-8 mediate activation of NF-κB by TRAIL
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Document Date: 2012-10-25 05:59:57

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File Size: 2,30 MB

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City

Munich / Hannover / Cambridge / Darmstadt / Hamburg / Santa Cruz / /

Company

Epitomics Inc. / Merck / BD Biosciences / Sigma-Aldrich / Macmillan Publishers Limited / /

Country

Germany / United States / United Kingdom / /

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Facility

TRAIL DISC / C terminus / Disease TRAIL / TRAIL C230S / Helmholtz Center / TRAIL M Grunert1 / C terminus of TRAIL-R1 / /

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IndustryTerm

active site / p43 cleavage product / cellular systems / cleavage site / chemical mutagenesis / protease cleavage site / /

MedicalCondition

tumor / Disease / SHEP neuroblastoma cells / increased inflammation / tumor necrosis / JURKAT T-cell leukemia / T-cell leukemia / Experimental Medicine Tumor necrosis factor / RIP1 deficiency / deficiency / TRAIL-sensitive neuroblastoma cell line SHEP / FADD deficiency / /

MedicalTreatment

anticancer therapy / /

Organization

Helmholtz Center Munich / Department of Gene Vectors / German Research Center for Environmental Health / DED / /

Person

Carl Roth / Gene Vectors / /

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Position

*Corresponding author / representative / reporter / Harper / /

Technology

antibodies / siRNA / Cell Signaling / DNA binding / apoptosis / /

URL

www.nature.com/cddis / /

SocialTag