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City Worcester / New York / / Company ADP / Elsevier Ltd. / / Country United States / / / Event Product Issues / / Facility RIP1-RIP3 complex / University of Massachusetts Medical School / RIP3 complex / / IndustryTerm treatment of these diseases / dedicated molecular machinery / mitochondrial energy metabolism / molecular signaling network / gene products / host apoptosis machinery / elaborate biochemical network / mitochondrial metabolism machinery / Chemical inhibitor / energy metabolism regulator / putative caspase cleavage site / / MedicalCondition necrotic cell injury / productive infection / anti-viral inflammatory responses / nonspecific cell injury / JE / e.g. heat shock / injury / immune deficiency / defective programmed necrosis / cerulein-induced pancreatitis / ROS production deficiency / spontaneous programmed necrosis / inflammatory diseases / RIP1-driven necrosis / clear why programmed necrosis / neuroblastoma metastasis / programmed necrosis / cancers / tumor / necrosis / tumors / viral programmed necrosis / ischemic brain injury / complex and programmed necrosis / Drosophila immune deficiency / Brooke-Spiegler syndrome / solid tumor / MCMV infection / vaccinia virus infections / virus-induced inflammation / tissue inflammation / auto-inflammatory diseases / malignant diseases / Tumor necrosis / tumor necrosis factor / innate inflammatory responses / RIP3-dependent Necrosis / diseases / certain viral infections / FADD deficiency / inflammatory form / cellular necrosis / / Organization National Institute of Health / Department of Pathology / National Academy of Sciences / IMD / DED / University of Massachusetts Medical School / Francis Ka-Ming Chan Department of Pathology / Immunology and Virology Program / / Person David Moquin / Tia Bumpus / Francis Ka-Ming Chan / / / Position Corresponding author / Author / important mediator / essential mediator / / Product programmed necrosis inhibitor M45 / RIP3 mutant / / ProvinceOrState Massachusetts / / PublishedMedium Proceedings of the National Academy of Sciences / / Technology alpha / siRNA / cell signaling / apoptosis / PDF / / SocialTag 
NIH Public Access Author Manuscript Trends Biochem Sci. Author manuscript; available in PMC 2011 August 1.