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Oncology / Phosphoinositide 3-kinase / AKT / PTEN / HER2/neu / Breast cancer / Akt/PKB signaling pathway / Phosphoinositide-dependent kinase-1 / Medicine / Biology / Protein kinases


Abstract 928 AACR 2012 The novel clinical candidate AT13148 is an oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity and a mechanism of action distinct from AKT inhibitors
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