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Cullin / Autophagy / NEDD8 / CAND1 / BTRC / Tuberous sclerosis protein / Von Hippel–Lindau tumor suppressor / CUL1 / Ubiquitin / Biology / Proteins / Mammalian target of rapamycin


Targeting Cullin-RING ligases by MLN4924 induces autophagy via modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis
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Document Date: 2012-09-06 06:12:07

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File Size: 1,04 MB

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City

Ann Arbor / Shanghai / /

Company

IgG mTOR Ab / Macmillan Publishers Limited / /

Country

United States / /

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Event

FDA Phase / /

Facility

Shanghai Medical College / Size bar / SCF complex / Fudan University / University of Michigan / /

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IndustryTerm

cancer therapy / genetic and pharmaceutical approaches / chemical screening / /

MedicalCondition

MLN4924 effectively killed cancer / tumor / Cancer Cullin-RING ligases / different tumor / cancer / Disease / human cancer / cancer lines / either deficiency / tuberous sclerosis / carcinomas / several human cancer / Disease cancer / /

MedicalTreatment

cancer therapy / /

Organization

Division of Radiation and Cancer Biology / Fudan University / University of Michigan / Shanghai Medical College / Department of Radiation Oncology / /

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Position

China *Corresponding author / representative / /

Product

MLN4924 / /

ProvinceOrState

Michigan / /

Technology

Radiation / siRNA / treating cancer / apoptosis / /

URL

www.nature.com/cddis / /

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