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Chemistry / Epigenetics / Cutaneous T-cell lymphoma / Methylation / DNA methylation / Mantle cell lymphoma / Arginine / Bisulfite sequencing / Large-cell lymphoma / Lymphoma / Biology / Genetics


Promoter methylation of argininosuccinate synthetase-1 sensitises lymphomas to arginine deiminase treatment, autophagy and caspase-dependent apoptosis
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Document Date: 2012-07-05 05:55:12

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City

ADI / Tainan / Leiden / Oxford / Exeter / Hitchin / Diego / Paisley / Dundee / Poole / Crawley / Ioannina / Cambridge / Watford / Salisbury / London / San Diego / /

Company

Roche Diagnostics / Smith RT. / Qiagen / Millipore Ltd / Beckman Coulter Ltd / Polaris Group / BD Biosciences / Polaris Pharmaceuticals Inc. / Cancer Research UK / Cambridge Bioscience Ltd / Tree Star Inc. / Sigma-Aldrich Co. / New England Biolabs Ltd / Creative Commons / Tennant / Macmillan Publishers Limited / /

Country

Netherlands / United Kingdom / Taiwan / United States / Greece / /

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Event

Product Issues / Funding / /

Facility

Leiden University Medical Center / University of Dundee / Clare Hall / Chi-Mei Medical Center / Charing Cross Campus / Cancer Institute / Queen Mary University of London / Ninewells Hospital / Potters Bar / Kaohsiung Medical University Hospital / College London / St John’s Institute of Dermatology / National Institute of Cancer Research / University Hospital of Ioannina / Kaohsiung Medical University / Charterhouse Square / Barts Cancer Institute / /

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IndustryTerm

cancer therapy / transcription start site / factor accounting / image acquisition software / treatment of cancer / therapy for cancer / degradation product / therapy for prostate cancer / treatment of patients with metastatic melanoma / /

MedicalCondition

unresectable hepatocellular carcinoma / ovarian cancer / haematological cancers / several solid tumours / autoimmune systemic lupus erythematosus / lymphoma cell lines / Follicular lymphoma / malignant lymphoma cell lines / melanoma / B-cell lymphomas / T lymphoma cells / prostate cancer / ASS1-methylated lymphoma cells / arginine deficiency / Sezary syndrome / malignant lymphoma samples / ASS1-methylated cutaneous T-cell lymphoma / malignant lymphoma cells / Leukemia / tumor / Cancer / lymphoma cell cytotoxicity / Jurkat leukaemia cell line / T-cell dysfunction / patient’s lymphoma / osteosarcoma / lymphomas / lymphoma cell studies / Hodgkin’s lymphomas / arginine starvation / primary follicular lymphomas / ASS1methylated lymphomas / infection / ASS1-methylated lymphoma cell lines / human T-lymphoblastic leukemia CCRFCEM / metastatic melanoma / Tumours / systemic lupus erythematosus / lymphoma / refractory lymphoma / lymphoma cell sensitivity / Asian advanced hepatocellular carcinoma / mantle cell lymphoma / J Cancer / ASS1-methylated lymphoma cell line susceptibility / primary and relapsed lymphomas / malignant pleural mesothelioma / ASS1 deficiency / pulmonary metastasis / follicular lymphoma methylome / B lymphoma cells / marginal zone lymphoma / primary lymphomas / MS / infections / lymphoma cell line / intercurrent infection / autophagy enhancing lymphoma cell apoptosis / cell lymphoma / cutaneous T-cell lymphoma / Disease / CTCL (MyLa) lymphoma cells / diffuse large B-cell lymphoma / ASS1-negative lymphoma viable cells / tumour / lymphoma cells / several solid cancers / Essentially tumours / nonresectable and metastatic hepatocellular carcinoma / lymphoma cell resistance / Only two malignant lymphoma samples / dC-treated lymphoma cells / T-cell lymphoma / patient’s pruritus / /

MedicalTreatment

cancer therapy / immunosuppression / antibiotics / /

NaturalFeature

Kuo MT / /

Organization

Ninewells Hospital / Centre for Molecular Oncology / Kaohsiung Medical University / Kaohsiung / Centre for Haemato-Oncology / John Vane Science Centre / Cancer Centre / St John’s Institute of Dermatology / Barts Cancer Institute / University of London / 2Barts Cancer Institute / Leiden University Medical Center / 7King’s College London / Chi-Mei Medical Center / 3Imperial College / University Hospital of Ioannina / University of Dundee / Research Ethics Committee / National Institute of Cancer Research / Kaohsiung Medical University Hospital / /

Person

Fellowship / John Bomalaski / Chaz Mein / Keyur Trivedi / Andrew Clear / Rosa V / Albino V / John Vane / Mohammed Ikram / Peter Szlosarek / Silvia Ferreira / /

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Position

Representative / *Corresponding author / Walker / Tsai WB / /

Product

dexamethasone / polyethylene glycol / ADI-PEG20.9 / phosSTOP / solid tumour cells.13 To test / /

ProvinceOrState

South Dakota / California / /

PublishedMedium

Cancer Research / /

Technology

apoptosis / Cell Signaling Technology / gene expression / treating cancer / antibodies / /

URL

www.nature.com/cddis / http /

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