| Document Date: 2015-03-05 19:45:26
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City IFN / Burnaby / / Company IgG / Gene Therapy Systems / BD Biosciences / Diebold / Central Laboratory / / Country United States / Canada / / Currency cent / / / Facility Central Laboratory / duplex WBC / duplex RNA / / IndustryTerm nonviral delivery systems / delivery systems / siRNA manufacturing process / similar chemical structure / ONLINE PUBLICATION NATURE BIOTECHNOLOGY / polycation solution / ONLINE PUBLICATION / ONLINE PUBLICATION β-gal / ONLINE PUBLICATION BP1 control / immunological systems / chemical modifications / / MedicalCondition inflammatory response / inflammatory reactions / leukopenia / inflammatory cytokine release / inflammatory cytokines / breast cancer / tumor necrosis factor-a / systemic inflammatory response / inflammatory cytokine release6 / inflammatory pathways / / MedicalTreatment drug targeting / / Organization Concurrent administration / PLL PEI / i.v. administration / Systemic administration / Canadian National Science and Engineering Research Council / / Person Vandana Sood / Nat / Janet R Shaw / James Heyes / Ian MacLachlan / Kevin McClintock / Lorne Palmer / Adam D Judge / Dianne Fang / / Position NF-kB reporter / representative / data representative / Judge / / Product Hypaque / penicillin / / ProvinceOrState British Columbia / / PublishedMedium NATURE BIOTECHNOLOGY / / Technology siRNA / BIOTECHNOLOGY / functional genomics / Drug Discovery / gene expression / 3g / / URL http /
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LETTERS Adam D Judge, Vandana Sood, Janet R Shaw, Dianne Fang, Kevin McClintock & Ian MacLachlan Luc control) induced substantial, dose-dependent interferon-a (IFN-a) responses in outbred ICR mice (Fig. 1a,b). This was