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Articles pubs.acs.org/acschemicalbiology Identification of a Small Molecule Yeast TORC1 Inhibitor with a Multiplex Screen Based on Flow Cytometry Jun Chen,*,†,‡ Susan M. Young,†,‡ Chris Allen,†,‡ Andrew Seebe
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Document Date: 2012-02-24 07:35:52


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File Size: 4,76 MB

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City

Geneva / Barbet / Moroni / Fribourg / Albuquerque / Gray / L. A. / Lawrence / /

Company

TOCRIS Biosciences / ACS / Carroll A. S. / Affymetrix / Armour / Gerke L. C. / Wilson / Dodson A. E. / Suzuki / Kang S. A. / ASSOCIATED CONTENT / /

Country

Switzerland / United States / /

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Event

FDA Phase / /

Facility

University of Fribourg / University of Geneva / University of New Mexico / University of Kansas / /

IndustryTerm

stock solution / chemical probes / therapy of many cancers / chemical fragmentation analysis / chemical genomics / complicated regulatory network / distinct chemical structure / treatment of cancer / chemical tools / gene chips / yeast gene chips / chemicals / efflux systems / /

MedicalCondition

therapeutic cancer / cancers / mitochondrial dysfunction / cancer / disease / diabetes / /

MedicalTreatment

bypass / AID / /

Organization

Center for Molecular Discovery / Group of 20 countries / University of Geneva / Department of Pathology / Department of Internal Medicine / Department of Biology / Swiss National Centre for Competence / Swiss National Foundation / Molecular Discovery / ‡Cancer Research and Treatment Center / Division of Biocomputing / University of Fribourg / Genetics and #Swiss National Centre for Competence / Division of Biochemistry / Department of Molecular Biology / University of Kansas / University of New Mexico / Department of Medicinal Chemistry / Chemistry Center / /

Person

M. Garcia / V / Andrew Seeber / Marie-Pierre Pe / Anna Waller / Margaret Werner-Washburne / J. Jacob Strouse / Nat / Alexa Fluor / Jennifer E. Golden / Chung / Ai / Mark B. Carter / Nolan / Blake R. Peterson / Larry A. Sklar / Susan M. Young / Bruce S. Edwards / Duensing / Robbie J. Loewith / Chris Allen / Oleg Ursu / Terry D. Foutz / Cristian G. Bologa / Jeffrey Aube / Nicolas Panchaud / Claudio De Virgilio / Trinkle / /

Position

RT / AUTHOR INFORMATION Corresponding Author *E-mail / central coordinator / T. D. / fundamental controller / G. P. / /

Product

Dev / SPS / amphotericin B / nitro / TOR / /

ProvinceOrState

Kansas / New Mexico / Nova Scotia / M. B. / North Carolina / /

PublishedMedium

Cancer Research / PLoS One / Molecular Biology / /

Technology

Genomics / chemical genomics / radiation / proteomics / hybridization / high-throughput screening / drug screening / RMA algorithm / drug discovery / DNA Chip / yeast gene chips / gene expression / multiplexing staining protocol / /

URL

http /