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RNA / Small interfering RNA / RNA interference / C5-convertase / Eculizumab / C5 / Complement component 5 / Complement membrane attack complex / Alternative complement pathway / Complement system / Biology / Genetics


ALN-CC5, an Investigational RNAi Therapeutic Targeting C5 for Complement Inhibition Anna Borodovsky1; Kristina Yucius1; Andrew Sprague1; Nirmal K. Banda2; V. Michael Holers2; Akshay Vaishnaw1; Martin Maier1; Rajeev Kalla
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Document Date: 2014-12-06 10:10:48

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City

Cambridge / ALN / Boston / /

Company

siRNA C5 Anti-C5 Ab / Convertase C3b Inflammation C5a siRNA C5 Anti-C5 Ab / IgG / Anti-C5 Ab / K. Y. A. S. / anti-Fx1a / CVF Serum C5 200 PBS Anti-C5 Ab / PBS Anti-C5 Ab / CC5 C5 12 Terminal Pathway Col Ab / Alnylam Pharmaceuticals / Benny Sorensen1 Alnylam Pharmaceuticals Inc. / Benny Sorensen 1 Alnylam Pharmaceuticals Inc. / /

Country

United States / /

Event

FDA Phase / /

Facility

University Medical School / University of Colorado School / /

IndustryTerm

treatment for patients with PNH and other disorders / /

MedicalCondition

anti-collagen antibody-induced arthritis / proteinuria / complement-mediated diseases / Passive Heymann Nephritis / C5 Silencing Reduces Proteinuria / disease / arthritis / SAD / inflammatory context / membranous nephropathy model / atypical hemolytic-uremic syndrome / Nephritis / paroxysmal nocturnal hemoglobinuria / Clinical disease / Terminal Pathway C5b Clinical Disease Activity C5b-C9 Membrane attack complex / inflammation / membranous nephropathy / disorders / /

MusicAlbum

Untreated / /

Organization

University of Colorado School of Medicine / Boston University Medical School / /

Person

Rachel Meyers / Kevin Fitzgerald / David J / David J. Salant / /

Position

driver / Representative / /

Product

Cobra / LPS injection / SC / RNAi therapeutics platform / C5 / RNAi / CC5 / /

ProgrammingLanguage

C / MAD / /

ProvinceOrState

Aurora / South Carolina / S. K. / Massachusetts / Colorado / /

SocialTag