OSI Pharmaceuticals / Ligand / Genentech / Pfizer / ATP / dinger LLC / Informa UK Ltd. / /
Country
United States / /
Currency
cent / /
Event
FDA Phase / /
Facility
Robert Roskoski Jr Blue Ridge Institute / /
IndustryTerm
active site / local spatial pattern alignment algorithm / cancer therapy / treatment of advanced lung cancer / actual site / treatment of NSCLC and other neoplastic disorders / peptide-binding site / crizotinib-binding site / indolinone / important chemical property / /
MedicalCondition
mm3 initial tumor / II lung cancers / neuroblastoma and anaplastic thyroid cancer / adenocarcinomas NPM-ALK / metastasis / Inflammatory myofibroblastic tumor / same tumor / advanced lung cancer / human cancers / nausea / colorectal cancers / neuroblastoma / non-small-cell lung cancers / small cell lung cancer / ALKpositive lung cancer / metastatic disease / anaplastic large-cell lymphoma / non-small-cell lung cancer / renal cell cancers / large-cell lymphoma / disorder / lymphopenia / complete tumor / diarrhea / Renal cell carcinoma / inflammatory fibroblastic tumors / myofibroblastic tumor / constipation / pneumonitis / head cancers / metastatic non-small-cell ALK-positive lung cancer / primary tumors / Lung cancers / esophageal cancers / smokers bearing adenocarcinomas / tumor / Introduction Cancer / breast cancers / Hereditary / rare mesenchymal neoplasms / cancer / tumors / disease / NSCLC / hypophosphatemia / patients experiencing tumor / neutropenia / Diffuse large B-cell lymphoma / ALCL Adults Breast cancer Colorectal cancer ALCL Adults Adults Children Inflammatory / unselected lung cancer / lymphomas / anaplastic large-cell lymphoma prompted drug discovery programs / vomiting / metastatic tumors / lung cancer / listed diseases / human osteogenic sarcoma / diseases / prevalent disease / neck cancers / aggressive tumors / human anaplastic lymphoma cell lines / anaplastic lymphoma kinase / carcinomas / neoplastic disorders / rhabdomyosarcomas / disorders / effectively inhibited tumor / /
MedicalTreatment
chemotherapy / radiotherapy / surgery / radiation / cancer therapy / bypass / adjuvant therapy / /
Organization
Robert Roskoski Jr Blue Ridge Institute for Medical Research / United States Food and Drug Administration / identified using the USFDA-approved FISH Probe Kit / /
Drug Discovery Case History 1. Introduction