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City Philadelphia / / Company Cephalon / Amgen / Elsevier Ltd. / Ge / Ligand / Moog / / Country United States / / Currency pence / / / Facility Blue Ridge Institute / / / IndustryTerm active site / treatment of renal cell cancer / online version / cancer therapy / treatment of lung cancer / lung cancer treatment / treatment of non-small cell lung cancer / peptide binding site / protein data bank / treatment of advanced lung cancer / actual site / phosphorylation site / peptide-binding site / treatment of Philadelphia chromosome positive chronic myelogenous leukemia / treatment of this disorder / treatment of colorectal cancer / alignment algorithm / / MedicalCondition neoplasms / ALK-positive non-small cell lung cancer / ALK-related cancers / advanced non-small cell lung carcinoma / rheumatoid arthritis / advanced lung cancer / Neuroblastoma / metastatic disease / small-cell lung cancer / SCLC / Lung carcinomas / disorder / non-small cell lung cancer / squamous cell cancer / illness / breast cancer / adenocarcinoma / tumor / Hereditary / non-Hodgkin lymphomas / cancer / schizophrenia / tumors / neoplasm / NSCLC / positive chronic myelogenous leukemia / nervous disorders / diabetes / Lymphomas / fever / bronchioloalveolar carcinoma / lymphoma kinase / Bronchioloalveolar lung cancer / anaplastic large cell lymphoma / diseases / ammatory myofibroblastic tumors / non-Hodgkin lymphoma / pulmonary hemorrhaging / depression / squamous cell lung carcinoma / non-Hodgkin lymphoma involving T-cells / disorders / Rhabdomyosarcoma / ALK-positive lung cancers / Large-cell lung carcinoma / anaplastic large-cell lymphomas / undifferentiated malignant neoplasms / colorectal cancer / large B-cell lymphoma / metastasis / neuroblastomas / several diseases / large-cell lymphomas / targeted diseases / often lethal childhood cancer / anaplastic large-cell lymphoma / anaplastic thyroid carcinomas / large-cell lymphoma / leukemias / renal cell carcinoma / Small cell lung cancers / lung cancers / cancers / childhood neuroblastomas / squamous cell carcinoma / adenocarcinomas / Anaplastic thyroid cancer / disease / Non-small cell lung cancer Lung cancer / newly diagnosed lymphomas / Protein kinase inhibitor Targeted cancer / large cell carcinoma / rst disorder / diffuse large B-cell lymphoma / human cancers.a Disease Chromosomal abnormalities Fusion protein / ammatory myofibroblastic tumor / non-small cell lung cancers / Hodgkin lymphoma / Localized primary cutaneous anaplastic largecell lymphomas / tumor necrosis / lung cancer / non-metastatic lung cancer / listed diseases / anaplastic lymphoma kinase / renal cell cancer / B-cell lymphoma / / MedicalTreatment radiotherapy / Surgery / radiation / cancer therapy / alternative therapies / chemotherapy / / Organization Blue Ridge Institute for Medical Research / National Academy of Sciences USA / National Institute of Health / BC CRC / ND ND / US Food and Drug Administration / / Person Robert Roskoski Jr. / R. Roskoski Jr. / / / Position General / / Product carboplatin / Koss P15 Headphone/Headset / oncovin / Avastin / prednisolone / paclitaxel / glycine / prednisone / Tarceva / cyclophosphamide / Iressa / Pyle P32 Television / / ProvinceOrState North Carolina / / Technology radiation / X-ray / ALE / apoptosis / Drug discovery / alignment algorithm / chemotherapy / treating cancer / antibodies / hybridization / / URL www.elsevier.com/locate/yphrs / http / SocialTag 
Anaplastic lymphoma kinase (ALK): Structure, oncogenic activation, and pharmacological inhibition